HPTLC Fingerprinting and Anti-asthmatic Activity of Roots of Two Different Sources of Bharangi

Indian Journal of Natural Products,2021,35,1,25-31.DOI:10.5530/ijnp.2021.1.6Published:February 2021Type:Original ArticleAuthors:Sagar Soundalgekar, Atish Naik, Kirankumar Hullatti, Sunil Jalalpure, Sneha Patil, and Vishakha Parab Gaonkar Author(s) affiliations:Sagar Soundalgekar1, Naik1, Hullatti2,*, Jalalpure1, Patil1, Gaonkar1 1Department Pharmacognosy, KLE College Pharmacy, Belagavi, Academy Higher Education Research, Karnataka, INDIA. 2Department Bengaluru, Abstract:The present research work aims at developing HPTLC fingerprints two sources Bharangi Clerodendrum serratum (Linn.) indicum (Linn.), along with in vivo antiasthmatic evaluation OVA-induced Wistar rat model. Air dried roots both plants were subjected for extraction by maceration followed soxhlet using ethanol (80%). Further a was developed the quantification Oleanolic acid Stigma sterol to distinguish plants. The anti-asthmatic activity Clerodenrum evaluated Ovalbumin induced model inflammatory parameters like absolute eosinophil count BALF, total leukocyte Blood, IgE antibodies serum histopathological changes lungs studied. fingerprinting showed presence it found be absent whereas Stigmasterol serratum. In activity, test drugs have shown significant decrease such as Absolute Total BALF Concentration antibodies. Among Extract treated groups CSE1 CSE2 good results p<0.0001 when compared asthmatic group. All studied clearly conclude that these controversial botanical identity can distinguished based on their physiochemical fingerprint profiles. suggest hydroalcoholic extracts significantly possess activity. Keywords:Anti-asthmatic Bharangi, indicum, serratum, HPTLCView:PDF (1.2 MB)